The Division of Neonatology expends substantial effort in both clinical and basic science research and enjoys international recognition for its work related to pulmonary vascular biology, and premature lung disease and lung development. Historically, large clinical investigations have included studies of surfactant treatment, nitric oxide therapy, the effect of early hydrocortisone on the incidence of bronchopulmonary dysplasia, and the effect of vitamin A on the premature immune system. Current areas of clinical investigation include early laser treatment of pre-threshold retinopathy of prematurity; post-PPHN systemic hypertension; the effect of dexamethasone on nitric oxide pathway metabolites; osteopenia of prematurity; aspiration and gram negative pneumonia in the development of bronchopulmonary dysplasia, booster surfactant during the development of bronchopulmonary dysplasia; the use of HVAC ultraviolet germicidal irradiation in decreasing nosocomial infections; the use of anti-staphyloccal antibodies to decrease nosocomial infection; the role of breast milk in preventing nosocomial infections; and varying oxygen concentrations levels for premature infant resuscitation.

The Division of Neonatology leads the Center for Developmental Biology of the Lung, a state-of-the-art translational and basic research facility comprising 7,000 sq. ft. of laboratory space plus surgical suites, offices, conference rooms, equipment rooms, dark rooms, etc. Extensive equipment and technical staff support an active research program with a focus on pulmonary development and lung injury and repair. Laboratory projects are currently focused on pulmonary vascular biology and epithelial growth factors. Models include the premature ventilated lambs, the fetal sheep ductal ligation-induced PPHN model developed in Buffalo, sheep congenital diaphragmatic hernia model, neonatal rabbit hyperoxia-induced fibrosis, and various transgenic mice lines. Laboratory collaborations are well established with Departments of Physiology, Pharmacology, Critical Care, Pathology, and Surgery.

Fellows in the first year identify a mentor and begin their research project. Ample time and support exists to allow the fellow to complete research projects over the time of his or her fellowship. Submission of abstracts and attendance at regional and international scientific meetings is strongly encouraged. It is expected that each fellow will submit at least one manuscript during their fellowship training.

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