The Division of Neonatology expends substantial effort in both clinical and basic science research and enjoys international recognition for its work related to pulmonary vascular biology, and premature lung disease and lung development. Historically, large clinical investigations have included studies of surfactant treatment, nitric oxide therapy, the effect of early hydrocortisone on the incidence of bronchopulmonary dysplasia, and the effect of vitamin A on the premature immune system.
The Division of Neonatology leads the Center for Developmental Biology of the Lung, a state-of-the-art translational and basic research facility comprising 7,000 sq. ft. of laboratory space plus surgical suites, offices, conference rooms, equipment rooms, dark rooms, etc. Extensive equipment and technical staff support an active research program with a focus on neonatal transition at birth, disorders of neonatal transition and neonatal resuscitation, pulmonary development, lung injury and repair. Models include the premature ventilated lambs, the fetal sheep ductal ligation-induced PPHN model developed in Buffalo, sheep congenital diaphragmatic hernia model, neonatal rabbit hyperoxia-induced fibrosis, and various transgenic mice lines. Laboratory collaborations are well established with Departments of Physiology, Pharmacology, Critical Care, Pathology, and Surgery.
Faculty members in our division have received funding from the NIH, American Academy of Pediatrics, foundations and industry. Faculty and fellows regularly present at Pediatric Academic Society annual meetings.
Clinical research and quality improvement areas of interest include early laser treatment of pre-threshold retinopathy of prematurity, improving care for infants with opioid withdrawal, CLABSI reduction, the role of breast milk in preventing nosocomial infection, varying oxygen concentration levels for premature infant resuscitation, the role of simulation in improving readiness for clinical care and low volume, high complexity procedures.
We are also evaluating the pathophysiology of necrotizing enterocolitis (NEC) and its relation to prematurity, enteral feeds, ischemia and transfusions as a translational project.
Since 2011, we have been a part of the NICHD neonatal research network - a consortium of 18 universities and affiliated neonatal intensive care units dedicated to conducting multicenter clinical trials to improve the outcomes for critically ill newborn infants. Fellows in the first year identify a mentor and begin their research project. Ample time and support exists to allow the fellow to complete research projects over the time of his or her fellowship. Submission of abstracts and attendance at regional and international scientific meetings is strongly encouraged. It is expected that each fellow will submit at least one manuscript during their fellowship training.