The Center participates in in IRB-approved clinical research and data registries involving leukodystrophy patients, including the World Wide Registry for Krabbe Disease and the emerging data collection initiative through GLIA.  Additionally, located on the medical campus is the Hunter James Kelly Research Institute.

Hunter James Kelly Research Institute (HJKRI) is dedicated to unlock the secrets of myelination in the nervous system and to find therapies for diseases of myelin such as Multiple Sclerosis, Leukodystrophies and Charcot-Marie-Tooth disease. HJKRI is supported by the University at Buffalo, Hunter Hope's Foundation, New York State and extramural funds.

The basic research conducted at the HJKRI is based on a multi-disciplinary approach to understand how myelin is formed, how it is damaged in disease, and how it may be repaired.  Myelin diseases cause neurological problems by interfering with neuronal and axon function, so an important focus of HJKRI is to understand, prevent and reverse axonal degeneration.  It uses a variety of state-of-the art approaches that include genetic models, bioinformatics, primary cultures of neuronal and glial cells form patients and animal models, neurophysiology and live imaging. 

Click here for detailed information on the HJKRI.